Dietary calcium supplements, magnesium, and you can phosphorus intakes and you will chance of heart attack within the Chinese grownups

Dietary calcium supplements, magnesium, and you can phosphorus intakes and you will chance of heart attack within the Chinese grownups

Controversial results have been reported about the association of calcium, magnesium, and phosphorus and stroke risk, but none in China. To investigate the association between dietary calcium, magnesium, phosphorus, and stroke incidence in Chinese adults, we collected data from the China Health and Nutrition Survey (CHNS) from 2004 to 2011, including 6411 participants aged 45–79 years and free of stroke at baseline. Diet was assessed by interviews combining 3-d 24-h food recalls and household food inventory weighing at each survey round. The stroke incident was identified based on the validated self-report. Multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For 32,024 person-years of follow-up, 179 stroke cases were documented. After adjustment for major lifestyle and dietary risk factors, calcium intake was positively associated with reduced stroke risk, and the HR of stroke comparing extreme quartiles was 0.53 (95% CI 0.29–0.96, Pdevelopment = 0.03). In further stratified analyses, significant heterogeneity across sex strata was found (Pcommunication = 0.03). Dietary calcium intake among men was more inversely related to stroke, with HRs being 0.33 (95% CI 0.15–0.76, P trend = 0.02), compared to 1.24 (95% CI 0.46–3.35, Ptrend = 0.89) among women. However, no significant association between stroke and magnesium or phosphorus was revealed. Our findings suggest that higher dietary calcium intake was associated with a lower risk of stroke in Chinese adults, particularly in men.


Due to the fact a beneficial cerebrovascular condition, heart attack is just about the leading factor in demise within the created and developing countries. A good 10% full annual death worldwide is estimated becoming attributable so you can it 1 . Possibly the coronary arrest survivors, everything 15–30% are forever disabled dos , which results in up to 113 billion handicap-modified life ages shed step 3 . China has got the highest projected lives danger of coronary arrest around the world (39.3%) according to 2016 globally load out-of problem (GBD) regional studies cuatro . Seem to, coronary arrest is a serious social health issue to own Asia for the up against the elevated ageing inhabitants. For this reason, identifying the fresh convertible chance things was clicking into cures and you will the advance out of lives top-notch coronary attack clients and cures regarding big socio-economic load.

Fat reduction calcium supplements, magnesium, and you can phosphorus consumption and you may likelihood of coronary attack in Chinese grownups

Whilst particular etiology isn’t totally elucidated, coronary arrest is generally experienced a disease about hereditary and you may ecological exposure items (specifically losing weight) or the interplay of these things. Extensive research means that slimming down modifications are extremely advantageous to eliminate the latest onset of heart attack 5,6,seven . A near relationship is present between calcium, magnesium, phosphorus, and vascular protection, which happen to be considered crucial wellness effects to have vascular problems simply because they normally handle vascular calcification and endothelial malfunction 8,nine . Up to now, several studies have tested the partnership ranging from this type of nourishment intake and coronary arrest risk 10,11,12 , nevertheless the email address details are contradictory. Such as for instance, research about European population demonstrated magnesium intake, however calcium supplements is actually rather about a lower threat of coronary arrest eleven . In contrast, in america, calcium intake, in place of magnesium, results in ong boys, magnesium intake are inversely in the stroke 12 . Also, most of these scientific studies was indeed held into the west communities with a high intakes of these nutrition 13,14 . But not, to your training, nothing known in regards to the organization away from dietary calcium supplements, magnesium, and you can phosphorus intakes that have heart attack frequency regarding the Chinese society. The average weight loss consumption of these micronutrients certainly one of Chinese individuals ingesting mostly bush-dependent dieting are reported to be less than that of Europeans and you can People in america that far more milk and you may meat issues 15 . Contained in this framework, a giant-size possible analysis in the Chinese society to complement the newest association’s evidence is undoubtedly called for. We, ergo, used analysis on the China Health insurance and Diet Questionnaire (CHNS) to check the connection ranging from losing weight calcium supplements, magnesium, and you will phosphorus intakes and you can further frequency off coronary arrest into the Chinese people.

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